Senior Principal Scientist (non-PhD), Protein Sciences
Company: Loxo Oncology, Inc.
Location: Louisville
Posted on: January 26, 2023
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Job Description:
Loxo@Lilly conducts discovery research, clinical development and
regulatory affairs for oncology, with the goal of creating a
pipeline of therapies that have the potential to make a meaningful
difference for patients. Loxo@Lilly was created in December 2019,
combining the Lilly Research Laboratories oncology organization and
Loxo Oncology, which was acquired by Lilly in early 2019. The unit
has team members in Louisville, CO, Indianapolis, IN, New York
City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and
Madrid, Spain.
This position offers the opportunity to be part of Loxo@Lilly's
discovery teams focused on creating novel, highly specific and
selective drugs for genetically identified targets. The Protein
Purification Scientist will support the internal and external
discovery research efforts across multiple projects and project
teams. This is an extremely important role where the right person
will be able to have a real impact on cutting-edge science, making
a real difference in patient's lives.
Roles and Responsibilities of the Position:
* Provide recombinant protein expression and protein purification
expertise to deliver proteins central to research activities for
small molecule discovery
* Understand the quality of proteins required for functional and
biophysical assays, and develop protocols to deliver well
characterized proteins accordingly
* Execute projects in an efficient manner, working with aggressive
timelines
* Values quality over quantity, with the ability to prioritize
* Rapidly communicate scientific results and insights to the
team
* Prepare reports for internal and external purposes including
regulatory submissions
* Participate and lead project-based and technical team meetings to
identify and solve problems, guide work towards project goals,
communicate on-going work and progress, and plan forward thinking
strategies
* Continually advance your understanding of current methodology and
emerging technologies by reading scientific literature
* Proactively investigate new or different technologies, methods,
and service providers to ensure our work is being done in a
scientifically sound, efficient, and reasonable way
Required Qualifications and Preferred Background:
* BA/BS/MS in protein sciences, biology, biochemistry, molecular
biology, or a related field along with hands-on experience, working
in a laboratory in a biotechnology/pharmaceutical setting
* 5+ years' experience with an MS degree; 8+ years' experience with
BS/BA degree); may also consider experience out of an
academic/research setting
* Strong team player who inspires colleagues to solve difficult
problems and develop efficient workflows
* Experience designing expression constructions for functional
assays and crystallography
* Proficient with molecular biology techniques including
cloning
* Expertise with a variety of protein expression systems including
E. coli and Baculovirus infected insect cells
* Expertise with protein purification techniques such as IMAC, SEC,
IEX and affinity chromatography is required, ideally utilizing the
AKTA FPLC systems
* Expertise with protein characterization techniques such as LCMS,
western blotting, and thermal stability assays, is desirable.
* Familiarity with biophysical and functional techniques such as
SPR, ASMS, fluorescent binding assays, and enzyme kinetic assays is
beneficial
* The candidate must be self-motivated but always maintain focus on
why we are here and who is important i.e. the patients and their
families/caregivers
* Excellent interpersonal skills with ability to communicate and
interact well with colleagues, vendors, contractors, scientific
advisors, and staff at all levels
* Desire and ability to flex between protein
expression/purification/characterization is a must
* Highly organized with excellent analytical, documentation and
multi-tasking skills
*
* Loxo Oncology, Inc. (Loxo) currently anticipates that the base
salary for the Senior Principal Scientist position level could
range from between $109,500 to $160,600 and will depend, in part,
on the successful candidate's qualifications for the role,
including education and experience. This position also will be
eligible for a company bonus (depending, in part, on company and
individual performance). In addition, Loxo provides a comprehensive
benefit program to eligible employees, including vacation, medical,
dental and vision benefits; participation in a 401(k) plan; life
and accidental death and disability coverage; parental leave
benefits and employee discounts for certain items. The compensation
described above is subject to change and could be higher or lower
than the range described above. Further, Loxo reserves the right to
amend, modify, or terminate its compensation and benefit programs
in its sole discretion.
Physical Demands/ Travel:
The physical demands of this job are consistent with light office
duties.
The physical demands here are representative of those that must be
met by an employee to successfully perform the essential functions
of this job.
Work Environment:
This position's work environment is in an office and the lab.
The work environment characteristics described here are
representative of those an employee encounters while performing the
essential functions of this job.
* To perform this job successfully, an individual must be able to
perform the role and responsibilities satisfactorily. The
requirements listed above are representative of the knowledge,
skill, and/or ability required. Reasonable accommodations may be
made to enable individuals with disabilities to perform the
essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action
Employer and does not discriminate on the basis of age, race,
color, religion, gender, sexual orientation, gender identity,
gender expression, national origin, protected veteran status,
disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its
subsidiaries in the United States and Puerto Rico, you must be
fully COVID-19 vaccinated and provide proof of vaccination
satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals
with disabilities participate in the workforce and ensure equal
opportunity to compete for jobs. If you are an individual with a
disability and require a reasonable accommodation to participate in
the application process for positions at Loxo, please email
loxoaccommodation@loxooncology.com for further assistance. Please
note, this email address is intended for use to request an
accommodation as a part of the application process. Any other
correspondence will not receive a response.
Keywords: Loxo Oncology, Inc., Louisville , Senior Principal Scientist (non-PhD), Protein Sciences, Other , Louisville, Kentucky
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