Senior Principal Scientist (non-PhD), Protein Sciences
Company: Loxo@Lilly
Location: Louisville
Posted on: January 27, 2023
Job Description:
Loxo@Lilly conducts discovery research, clinical development and
regulatory affairs for oncology, with the goal of creating a
pipeline of therapies that have the potential to make a meaningful
difference for patients. Loxo@Lilly was created in December 2019,
combining the Lilly Research Laboratories oncology organization and
Loxo Oncology, which was acquired by Lilly in early 2019. The unit
has team members in Louisville, CO, Indianapolis, IN, New York
City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and
Madrid, Spain.This position offers the opportunity to be part of
Loxo@Lilly's discovery teams focused on creating novel, highly
specific and selective drugs for genetically identified targets.
The Protein Purification Scientist will support the internal and
external discovery research efforts across multiple projects and
project teams. This is an extremely important role where the right
person will be able to have a real impact on cutting-edge science,
making a real difference in patient's lives.Roles and
Responsibilities of the Position:
- Provide recombinant protein expression and protein purification
expertise to deliver proteins central to research activities for
small molecule discovery
- Understand the quality of proteins required for functional and
biophysical assays, and develop protocols to deliver well
characterized proteins accordingly
- Execute projects in an efficient manner, working with
aggressive timelines
- Values quality over quantity, with the ability to
prioritize
- Rapidly communicate scientific results and insights to the
team
- Prepare reports for internal and external purposes including
regulatory submissions
- Participate and lead project-based and technical team meetings
to identify and solve problems, guide work towards project goals,
communicate on-going work and progress, and plan forward thinking
strategies
- Continually advance your understanding of current methodology
and emerging technologies by reading scientific literature
- Proactively investigate new or different technologies, methods,
and service providers to ensure our work is being done in a
scientifically sound, efficient, and reasonable wayRequired
Qualifications and Preferred Background:
- BA/BS/MS in protein sciences, biology, biochemistry, molecular
biology, or a related field along with hands-on experience, working
in a laboratory in a biotechnology/pharmaceutical setting
- 5+ years' experience with an MS degree; 8+ years' experience
with BS/BA degree); may also consider experience out of an
academic/research setting
- Strong team player who inspires colleagues to solve difficult
problems and develop efficient workflows
- Experience designing expression constructions for functional
assays and crystallography
- Proficient with molecular biology techniques including
cloning
- Expertise with a variety of protein expression systems
including E. coli and Baculovirus infected insect cells
- Expertise with protein purification techniques such as IMAC,
SEC, IEX and affinity chromatography is required, ideally utilizing
the AKTA FPLC systems
- Expertise with protein characterization techniques such as
LCMS, western blotting, and thermal stability assays, is
desirable.
- Familiarity with biophysical and functional techniques such as
SPR, ASMS, fluorescent binding assays, and enzyme kinetic assays is
beneficial
- The candidate must be self-motivated but always maintain focus
on why we are here and who is important i.e. the patients and their
families/caregivers
- Excellent interpersonal skills with ability to communicate and
interact well with colleagues, vendors, contractors, scientific
advisors, and staff at all levels
- Desire and ability to flex between protein
expression/purification/characterization is a must
- Highly organized with excellent analytical, documentation and
multi-tasking skills
- Loxo Oncology, Inc. (Loxo) currently anticipates that the base
salary for the Senior Principal Scientist position level could
range from between $109,500 to $160,600 and will depend, in part,
on the successful candidate's qualifications for the role,
including education and experience. This position also will be
eligible for a company bonus (depending, in part, on company and
individual performance). In addition, Loxo provides a comprehensive
benefit program to eligible employees, including vacation, medical,
dental and vision benefits; participation in a 401(k) plan; life
and accidental death and disability coverage; parental leave
benefits and employee discounts for certain items. The compensation
described above is subject to change and could be higher or lower
than the range described above. Further, Loxo reserves the right to
amend, modify, or terminate its compensation and benefit programs
in its sole discretion.Physical Demands/ Travel:The physical
demands of this job are consistent with light office duties. The
physical demands here are representative of those that must be met
by an employee to successfully perform the essential functions of
this job.Work Environment:This position's work environment is in an
office and the lab. The work environment characteristics described
here are representative of those an employee encounters while
performing the essential functions of this job.*To perform this job
successfully, an individual must be able to perform the role and
responsibilities satisfactorily. The requirements listed above are
representative of the knowledge, skill, and/or ability required.
Reasonable accommodations may be made to enable individuals with
disabilities to perform the essential functions.Loxo@Lilly (Eli
Lilly and Company) is an EEO/Affirmative Action Employer and does
not discriminate on the basis of age, race, color, religion,
gender, sexual orientation, gender identity, gender expression,
national origin, protected veteran status, disability or any other
legally protected status.As a condition of employment with Eli
Lilly and Company and its subsidiaries in the United States and
Puerto Rico, you must be fully COVID-19 vaccinated and provide
proof of vaccination satisfactory to the company (subject to
applicable law).Loxo@Lilly (Eli Lilly and Company) is committed to
help individuals with disabilities participate in the workforce and
ensure equal opportunity to compete for jobs. If you are an
individual with a disability and require a reasonable accommodation
to participate in the application process for positions at Loxo,
please email for further assistance. Please note, this email
address is intended for use to request an accommodation as a part
of the application process. Any other correspondence will not
receive a response.
Keywords: Loxo@Lilly, Louisville , Senior Principal Scientist (non-PhD), Protein Sciences, Other , Louisville, Kentucky
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