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Senior Principal Scientist (non-PhD), Protein Sciences

Company: Loxo@Lilly
Location: Louisville
Posted on: January 27, 2023

Job Description:

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.This position offers the opportunity to be part of Loxo@Lilly's discovery teams focused on creating novel, highly specific and selective drugs for genetically identified targets. The Protein Purification Scientist will support the internal and external discovery research efforts across multiple projects and project teams. This is an extremely important role where the right person will be able to have a real impact on cutting-edge science, making a real difference in patient's lives.Roles and Responsibilities of the Position:

  • Provide recombinant protein expression and protein purification expertise to deliver proteins central to research activities for small molecule discovery
  • Understand the quality of proteins required for functional and biophysical assays, and develop protocols to deliver well characterized proteins accordingly
  • Execute projects in an efficient manner, working with aggressive timelines
  • Values quality over quantity, with the ability to prioritize
  • Rapidly communicate scientific results and insights to the team
  • Prepare reports for internal and external purposes including regulatory submissions
  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies
  • Continually advance your understanding of current methodology and emerging technologies by reading scientific literature
  • Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable wayRequired Qualifications and Preferred Background:
    • BA/BS/MS in protein sciences, biology, biochemistry, molecular biology, or a related field along with hands-on experience, working in a laboratory in a biotechnology/pharmaceutical setting
    • 5+ years' experience with an MS degree; 8+ years' experience with BS/BA degree); may also consider experience out of an academic/research setting
    • Strong team player who inspires colleagues to solve difficult problems and develop efficient workflows
    • Experience designing expression constructions for functional assays and crystallography
    • Proficient with molecular biology techniques including cloning
    • Expertise with a variety of protein expression systems including E. coli and Baculovirus infected insect cells
    • Expertise with protein purification techniques such as IMAC, SEC, IEX and affinity chromatography is required, ideally utilizing the AKTA FPLC systems
    • Expertise with protein characterization techniques such as LCMS, western blotting, and thermal stability assays, is desirable.
    • Familiarity with biophysical and functional techniques such as SPR, ASMS, fluorescent binding assays, and enzyme kinetic assays is beneficial
    • The candidate must be self-motivated but always maintain focus on why we are here and who is important i.e. the patients and their families/caregivers
    • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels
    • Desire and ability to flex between protein expression/purification/characterization is a must
    • Highly organized with excellent analytical, documentation and multi-tasking skills
    • Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Principal Scientist position level could range from between $109,500 to $160,600 and will depend, in part, on the successful candidate's qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.Physical Demands/ Travel:The physical demands of this job are consistent with light office duties. The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.Work Environment:This position's work environment is in an office and the lab. The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

Keywords: Loxo@Lilly, Louisville , Senior Principal Scientist (non-PhD), Protein Sciences, Other , Louisville, Kentucky

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